Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.
Identifieur interne : 000575 ( Main/Exploration ); précédent : 000574; suivant : 000576Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.
Auteurs : Ayokunle O. Ademosun ; Ganiyu Oboh ; Sabina Passamonti ; Federica Tramer ; Lovro Ziberna ; Aline Augusti Boligon ; Margareth Linde AthaydeSource :
- Journal of basic and clinical physiology and pharmacology [ 2191-0286 ] ; 2015.
English descriptors
- KwdEn :
- Caco-2 Cells, Cell Line, Tumor, Citrus (chemistry), Colonic Neoplasms (drug therapy), Colonic Neoplasms (metabolism), Fruit (chemistry), Humans, Metalloproteases (antagonists & inhibitors), Phenols (chemistry), Phenols (pharmacology), Plant Extracts (chemistry), Plant Extracts (pharmacology), Proteasome Endopeptidase Complex (drug effects).
- MESH :
- chemical , antagonists & inhibitors : Metalloproteases.
- chemistry : Citrus, Fruit, Phenols, Plant Extracts.
- chemical , drug effects : Proteasome Endopeptidase Complex.
- drug therapy : Colonic Neoplasms.
- metabolism : Colonic Neoplasms.
- chemical , pharmacology : Phenols, Plant Extracts.
- Caco-2 Cells, Cell Line, Tumor, Humans.
Abstract
Citrus peels are consumed in the form of infusions, candy or wine, based on their well-documented nutritional and medicinal properties. This study sought to investigate the effect of some citrus peels' [grapefruit (Citrus paradisii), orange (Citrus sinensis) and shaddock (Citrus maxima)] extracts on matrix metalloproteinase (MMP) and proteasome activities in primary human colonic tumor (Caco-2) and the metastatic cell lines (LoVo and LoVo/ADR) in a bid to explain the possible mechanism by which the peels could manage/prevent colon cancer.
DOI: 10.1515/jbcpp-2013-0127
PubMed: 26030791
Affiliations:
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Le document en format XML
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Ademosun</name></author><author><name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name></author><author><name sortKey="Passamonti, Sabina" sort="Passamonti, Sabina" uniqKey="Passamonti S" first="Sabina" last="Passamonti">Sabina Passamonti</name></author><author><name sortKey="Tramer, Federica" sort="Tramer, Federica" uniqKey="Tramer F" first="Federica" last="Tramer">Federica Tramer</name></author><author><name sortKey="Ziberna, Lovro" sort="Ziberna, Lovro" uniqKey="Ziberna L" first="Lovro" last="Ziberna">Lovro Ziberna</name></author><author><name sortKey="Boligon, Aline Augusti" sort="Boligon, Aline Augusti" uniqKey="Boligon A" first="Aline Augusti" last="Boligon">Aline Augusti Boligon</name></author><author><name sortKey="Athayde, Margareth Linde" sort="Athayde, Margareth Linde" uniqKey="Athayde M" first="Margareth Linde" last="Athayde">Margareth Linde Athayde</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26030791</idno><idno type="pmid">26030791</idno><idno type="doi">10.1515/jbcpp-2013-0127</idno><idno type="wicri:Area/PubMed/Corpus">000136</idno><idno type="wicri:Area/PubMed/Curation">000136</idno><idno type="wicri:Area/PubMed/Checkpoint">000136</idno><idno type="wicri:Area/Ncbi/Merge">001B56</idno><idno type="wicri:Area/Ncbi/Curation">001B56</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B56</idno><idno type="wicri:Area/Main/Merge">000575</idno><idno type="wicri:Area/Main/Curation">000575</idno><idno type="wicri:Area/Main/Exploration">000575</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.</title><author><name sortKey="Ademosun, Ayokunle O" sort="Ademosun, Ayokunle O" uniqKey="Ademosun A" first="Ayokunle O" last="Ademosun">Ayokunle O. Ademosun</name></author><author><name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name></author><author><name sortKey="Passamonti, Sabina" sort="Passamonti, Sabina" uniqKey="Passamonti S" first="Sabina" last="Passamonti">Sabina Passamonti</name></author><author><name sortKey="Tramer, Federica" sort="Tramer, Federica" uniqKey="Tramer F" first="Federica" last="Tramer">Federica Tramer</name></author><author><name sortKey="Ziberna, Lovro" sort="Ziberna, Lovro" uniqKey="Ziberna L" first="Lovro" last="Ziberna">Lovro Ziberna</name></author><author><name sortKey="Boligon, Aline Augusti" sort="Boligon, Aline Augusti" uniqKey="Boligon A" first="Aline Augusti" last="Boligon">Aline Augusti Boligon</name></author><author><name sortKey="Athayde, Margareth Linde" sort="Athayde, Margareth Linde" uniqKey="Athayde M" first="Margareth Linde" last="Athayde">Margareth Linde Athayde</name></author></analytic><series><title level="j">Journal of basic and clinical physiology and pharmacology</title><idno type="eISSN">2191-0286</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Caco-2 Cells</term><term>Cell Line, Tumor</term><term>Citrus (chemistry)</term><term>Colonic Neoplasms (drug therapy)</term><term>Colonic Neoplasms (metabolism)</term><term>Fruit (chemistry)</term><term>Humans</term><term>Metalloproteases (antagonists & inhibitors)</term><term>Phenols (chemistry)</term><term>Phenols (pharmacology)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Proteasome Endopeptidase Complex (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Metalloproteases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term><term>Fruit</term><term>Phenols</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Proteasome Endopeptidase Complex</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Colonic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Colonic Neoplasms</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Phenols</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Caco-2 Cells</term><term>Cell Line, Tumor</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Citrus peels are consumed in the form of infusions, candy or wine, based on their well-documented nutritional and medicinal properties. This study sought to investigate the effect of some citrus peels' [grapefruit (Citrus paradisii), orange (Citrus sinensis) and shaddock (Citrus maxima)] extracts on matrix metalloproteinase (MMP) and proteasome activities in primary human colonic tumor (Caco-2) and the metastatic cell lines (LoVo and LoVo/ADR) in a bid to explain the possible mechanism by which the peels could manage/prevent colon cancer.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ademosun, Ayokunle O" sort="Ademosun, Ayokunle O" uniqKey="Ademosun A" first="Ayokunle O" last="Ademosun">Ayokunle O. Ademosun</name><name sortKey="Athayde, Margareth Linde" sort="Athayde, Margareth Linde" uniqKey="Athayde M" first="Margareth Linde" last="Athayde">Margareth Linde Athayde</name><name sortKey="Boligon, Aline Augusti" sort="Boligon, Aline Augusti" uniqKey="Boligon A" first="Aline Augusti" last="Boligon">Aline Augusti Boligon</name><name sortKey="Oboh, Ganiyu" sort="Oboh, Ganiyu" uniqKey="Oboh G" first="Ganiyu" last="Oboh">Ganiyu Oboh</name><name sortKey="Passamonti, Sabina" sort="Passamonti, Sabina" uniqKey="Passamonti S" first="Sabina" last="Passamonti">Sabina Passamonti</name><name sortKey="Tramer, Federica" sort="Tramer, Federica" uniqKey="Tramer F" first="Federica" last="Tramer">Federica Tramer</name><name sortKey="Ziberna, Lovro" sort="Ziberna, Lovro" uniqKey="Ziberna L" first="Lovro" last="Ziberna">Lovro Ziberna</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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